David Sinclair· PhD
In 2008, we proposed that aging is driven by the redistribution of SIRT1 away from retrotransposon DNA, leading to their activation - evidence for the Information Theory of Aging (ITOA) originally called RCM
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
In 2008, we proposed that aging is driven by the redistribution of SIRT1 away from retrotransposon DNA, leading to their activation - evidence for the Information Theory of Aging (ITOA) originally called RCM
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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In 2008, our showed the most prevalent retrotransposons in the genome, eg LINE-1 are derepressed during aging due to Sirtuins leaving their post to repair broken DNA (Oberdoerffer et al, Cell, 2008) forming the basis of the Information Theory of Aging (ITOA)
In 2008, we showed the loss of SIRT1 and activation of retrotransposons happens during aging and contributes to epigenetic noise…