The immune system detects foreign pathogens without prior knowledge and tolerates self-antigens.

“it is remarkable to me how our immune systems evolved and they have this really brutal task which is how can they be tuned to detect any foreign pathogen that is harmful without knowing a priority what that could be while at the same so in other words how can you tune a system to be so aggressive that it can eradicate any virus or bacteria billions of years into the future without knowing what it's going to be but at the same time it has to be so forgiving of the self that it doesn't turn around and attack the self”

“it is remarkable to me how our immune systems evolved and they have this really brutal task which is how can they be tuned to detect any foreign pathogen that is harmful without knowing a priority what that could be while at the same so in other words how can you tune a system to be so aggressive that it can eradicate any virus or bacteria billions of years into the future without knowing what it's going to be but at the same time it has to be so forgiving of the self that it doesn't turn around and attack the self it's remarkable”