The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
you are right absolutely right I think it's both • you you know when it comes to mitophagy you know these all mitochondria it's been shown in insect in rodents that this is improved with caloric restriction autoag of course all these organel in the cells
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there's both mechanism less energy requirement but also more efficient mitochondria
but we measured mitochondrial turnover by by this method and we found that it was increased with • caloric restriction
we did measure mitochondrial biogenesis by looking at the relationship between nuclear • um markers and mitochondrial DNA and we • observed in humans that there was an increased mitochondrial biogenesis despite the fact that you use less energy you become more efficient you in you increase your biogenesis of of mitochondria which is quite spectacular because the Ross production of these react reactive oxygen species are produced by older mitochondria the new mitochondria are much more efficient they they they don't produce as many rust
you're saying that the people in the CR group had a greater turnover of their mitochondria yep and it's interesting muscle skeletal muscle he was yeah and and so we would expect that people who were calorically restricted would have lower Ross generation but we would expect that the reason for that is lower substrate utilization you're saying yeah they had lower Ross generation but it might actually be just as much from the fact that they had more mitochondrial biogenesis and they were using newer machinery for the substrate utilization so it could be both of those things are reducing Ross is that what you're saying
we did measure mitochondrial biogenesis by looking at the relationship between nuclear um markers and mitochondrial DNA and we uh observed in humans that there was an increased mitochondrial bio Genesis despite the fact that you use less energy you become more efficient you improve you increase your biogenesis of of mitochondria which is quite spectacular because the Ross production of these react reactive oxygen species are produced by older mitochondria the new mitochondria are much more efficient they they don't produce as many Ross