GLP-1RA treatment reversed aging-related gene expression in pathways such as synaptic signaling, metabolic programs, cellular senescence, oxidative phosphorylation, proteostasis, and autophagy.

“The specific disruption of GLP1 receptors expression in the hypothalamus diminished the transcriptomic and epigenetic age reversal across multiple tissues and organs including the frontal cortex, circulating white blood cells, the heart, and skeletal muscles, with hippocampal transcriptomic rejuvenation largely preserved but DNA methylation rejuvenation reduced.”

“Restored youthful gene expression (transcriptomics) and epigenetic (DNA methylation) patterns in aging mice, across multiple tissues including; brain regions (hypothalamus, hippocampus, frontal cortex), gonadal adipose (fat) tissue, circulating white blood cells, heart, skeletal muscle, colon (at the transcriptomic but not clearly the methylation level), liver and kidney.”