David Sinclair· PhD
Of all the various types of DNA damage, double stranded DNA breaks (DSBs) are believed to be the most potent cause of aging.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Of all the various types of DNA damage, double stranded DNA breaks (DSBs) are believed to be the most potent cause of aging.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
New paper in Cell @UofR implicates DNA double-strand breaks (DSB) as a driver of aging.