David Sinclair· PhD
Now, VEGF will be secreted out of the muscle and diffuse or just leak out into the lining of blood vessels. Now, the lining of the blood vessels is made of cells called endothelial cells which pick up the signal, they have little receptors that sense VEGF. And when they get that signal that says, "Oh wow, we're being chased by a saber tooth tiger for the last week, we better build more blood vessels," and they do that.