The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's unquestionably this as unsexy as it is like who cares about biomarkers but like without them I don't think we're going to get great answers because you can't do most of the experiments you and I would dream up
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
we want biomarkers to predict if we're targeting aging right we don't want to do phase three studies for every drug that we have and spend billion of dollar over five years to find that it doesn't work we need something that will show it in weeks or months that it's doing that
if you can show me that you create this test and then you go do a separate experiment and you can predict when the mice are six months old how long they're gonna live at an individual level i'm impressed and if you can show that this intervention when you treat them makes the signature go in the way that you think it should go and you can predict they're going to live 30 longer i'm even more impressed i'll believe it at that point
someone's gotta pony up a lot of money to develop the foundation of a pyramid that will ultimately become a great tool for drug discovery and a much more streamlined manner in which we could do clinical trials around this
at least for me what would be really valuable would be blood-based biomarkers potentially more elaborate but let's start with the blood where you could do interventions for a short period of time and if in fact those interventions would if continued lead to better lifespan or health span and let's just keep it simple and say lifespan they would show up
it's unquestionably this as unsexy as it is like who cares about biomarkers but like without them I don't think we're going to get great answers
we really don't have biomarkers for aging and you've been open about frustrations with that because when you look at geoprotective molecules and you look at if these things are working or not we really don't know because we don't have those biomarkers
we don't have great biomarkers for those things and that's largely thwarted our ability to test molecules that may or may not be gor protective