David Sinclair· PhD
Starvation hormone FGF21 increases survival in mice by 30% in males and 40% in females without decreasing food intake & apparently not via the usual suspects, NAD+, AMPK or mTOR.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Starvation hormone FGF21 increases survival in mice by 30% in males and 40% in females without decreasing food intake & apparently not via the usual suspects, NAD+, AMPK or mTOR.
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the interesting thing there is fgf21 overexpression by itself has also been reported to be sufficient to extend lifespan and mice