Differences in circulating products between species may explain the lack of benefit from human parabiosis experiments compared to mice.

“why would you think given how favorable this has been in mice it would not occur in humans that the products that in Ed up in the circulation of humans was a very different nature than in mice I mean uh you know the number of things that differ between humans and mice and blood would be enormous so pinning it down would be but I think there probably uh is some reason to suspect that it may work”

“Of course parabiosis itself is not a therapeutic regimen. I mean, presumably, you would not be too keen to do that.”