Calcium influx into brain cells during a concussion leads to vasoconstriction and decreased cerebral blood flow, contributing to a metabolic mismatch.

“you have this uh movement of the brain relative to its its uh protection in the skull the membrane of the neuron stretches so presumably it's you have a passive effusion of potassium out of the neuron as a result of that is the demand for glycolysis so that you can actively pump potassium back in against an unfavorable gradient correct”

“When the brain moves inside the skull the membrane to the neuron will stretch and when that membrane stretches this little little chemical called potassium which is supposed to be inside the neuron will leak into the extracellular space and when that does there's an increased demand for glucose or energy that occurs due to the release of potassium at the same time does it influx a calcium so calcium leaks across that same stretch membrane goes into the cell and when calcium goes into the cell we get vasoconstriction and decrease cerebral blood flow”

“and when that Pals when that calcium goes into the cell you know we get a vasoconstriction decreased cerebral blood flow and this is very clearly an energy crisis for what we call a metabolic mismatch that occurs to the cell”