The entourage effect in cannabis refers to the idea that THC's effects are different when combined with other molecules from the plant compared to isolated THC.

“people tend to refer to this as like an Entourage effect that's kind of a phrase that gets used quite widely in the Cannabis world and the idea behind that is that if you took pure THC um and so there are some like distillate pens and things that exist out there now in the product Market which are basically isolated THC with Trace levels of anything of other stuff would be very different than if you had THC in combination with some of these other molecules and how they might influence how THC itself is working or not”