David Sinclair· PhD
Here we report this mouse doesn’t live longer that control mice…
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Here we report this mouse doesn’t live longer that control mice…
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the evidence that sirtuins are potent regulators of lifespan in mice is mixed it's not strong there are a couple of studies out of probably you know a dozen that have been published and there's probably two dozen that are unpublished where people saw no effects on lifespan from manipulator or activating sirtuins
there are a couple of studies that show in one case a brain specific activation of one of the sirtuins called certio1 could slightly extend lifespan and another that that over expression of a different sir 2 in 36 could slightly extend lifespan i think only in males
the evidence that sirtuins are potent regulators of lifespan in mice is mixed it's not strong there are a couple of studies out of probably you know a dozen that have been published and there's probably two dozen that are unpublished where people saw no effects on lifespan from manipulator or activating sirtuins