Activation of TRP receptors by heat, cold, or capsaicin can activate longevity genes that fight disease and extend lifespan in model organisms.

“Transient receptor potential (TRP) ion channels that detect heat also detect chili & can extend lifespan in nematodes.”

“When TRP receptors sense hot, cold and spicy, they turn on longevity genes that fight disease and can extend lifespan in worms & flies.”