Peter Attia· MD
the KM, in other words, a 50% concentration of glycerol you needed for it to be phosphorylated was something like 100 millimolar. Enormous concentration. Huge. Like 100 to 1,000 fold higher unit ever found in a cell.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the KM, in other words, a 50% concentration of glycerol you needed for it to be phosphorylated was something like 100 millimolar. Enormous concentration. Huge. Like 100 to 1,000 fold higher unit ever found in a cell.
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he got this KM now of like... micromolar.
he found an activity associated with SARC that would phosphorylate glycerol. And he published it in JBC. It co-purified with the protein through numerous steps of purification. And so in addition to having the ability to phosphorylate tyrosine, antibodies that got phosphorylated on tyrosine, on the purified protein, there was also an activity there that phosphorylated glycerol.