Restricting certain amino acids like methionine or tryptophan in mice leads to increased food intake, no weight gain, and slightly longer lifespan.

“however what the current political uh interest around this idea doesn't tell is that the same groups actually said I know it can't be just the calories let's let's find out and investigate what exactly is causing the increasing lifespan and they found out that you can achieve the exact same extension even if in fact even further a larger extension of the maximum lifespan by by restricting specific amino acids upon the diet you can eat as many calories as you want right in fact some of the animals they had these amino acid restrictors they kept eating even two times or three times more calories they did not gain weight and they still live longer”

“the branch chain amino acid and and methionine restrictions studies are are pretty clear that those animals are consuming more calories more calories than that certainly if you match a weight then they add libidum mice and they're living longer”

“when you restrict for certain amino acids you're if you're deficient for a a a methionine for example or tryptophan the mice absolutely will eat more and they don't gain weight and they do seem to live a little bit longer”