David Sinclair· PhD
LCA also increases health and lifespan in nematode worms and flies...
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
LCA also increases health and lifespan in nematode worms and flies...
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The 1st paper by Qu et al. shows lithocholic acid (LCA) alone can recapitulate the effects of calorie restriction (CR) in mice, including AMPK activation, muscle regeneration & increased grip strength and running capacity.
The 2nd paper demonstrates that LCA reproduces the benefits of CR via a TULP3–sirtuin–AMPK pathway that requires direct SIRT1 activation...