Andrew Huberman· PhD
it certainly offered protection against infections especially parastic infections in the CNS which would have been a really important thing to select for 200,000 years ago
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it certainly offered protection against infections especially parastic infections in the CNS which would have been a really important thing to select for 200,000 years ago
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we actually think the E4 isopor offered a lot of advantages back in the day it's a bit of a pro-inflammatory — isopor and it certainly offered protection against infections especially parastic infections in the CNS which would have been a really important thing to select for 200,000 years ago
it seems to cause a more targeted and greater immune response to whatever insult be that in the brain or peripherally so you're better off at fighting fighting off whatever infection is or whatever install is that you're exposed to
and during that time it was beneficial because it may have protected us from infection
ApoE4 is actually protective for that actually helps does a huge number of things modulating the immune system modulating the immune response and it seems to be beneficial in that setting so it may have been a survival advantage due to the its effects on the immune system
it seems to cause a more targeted and greater immune response to whatever insult be that in the brain or peripherally so you're better off at fighting fighting off whatever infection is or whatever install is that you're exposed to
if you are living in a place where parasites are common and they're constantly testing your immune system you are much better off carrying the apoe4 allele than not locally the macrophage is much better equipped to deal with the parasite and importantly your brain is much better equipped to deal with whether it's tb meningitis and the mother would be better equipped to fight a septic event during childbirth
we know now that apoe4 women had a better chance of giving childbirth and protection from perpetual sepsis compared to non-e4 women in the slums of brazil or in certain areas in africa we know that based on studies that e4 confers some form of an advantage