The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Contracting skeletal muscle releasing myocin interfaces with cells of the immune system we've all heard of macras and the cytokine storm in Lucan 15 uh tnf tnf Alpha as being uh pro-inflammatory when the myocin which are also in Lucan 6 and interlan 15 are released from skeletal muscle they interplay and they somewhat dampen the inflammatory effect and have a different effect on the entirety of the system when these quote cyto kindes come from skeletal muscle
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some myokines are a little more sensitive to exercise intensity so is 6 was uh is one probably one of the most uh well-known myocin so it it it does play a role in inflammation but um when it's produced from muscle during exercise it's not it it's it's signaling to um other tissues to have an anti-inflammatory response and so um you'll often find a even larger production of anti-inflammatory cyto such as is 10 in response to is 6 produced during exercise