The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
But what a wonderful student, Wan Chang Lu did a few years ago in my lab was he found a set of genes that are Yamanaka factors that were able to reverse the age of cells and tissues in an animal and in human cells to a certain point, going back about 80% of age, but not to zero. So that this was a new, safe approach to reversing the age of the body without any negative side effects.
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So we left those out, and surprisingly those other three, O, S, and K for short, worked. Not just in cells in the dish, but even in the whole animal.
Four of them so-called Yamanaka factors or OSKM as an abbreviation. These will very convincingly take a very old cell and turn it into a very young cell, maybe like, say, a skin cell from 80 year old. It will take on many of the characteristic...most of the significant characteristics of an embryonic cell in that it can produce almost all the tissues of the body, probably all of them, except for the extra-embryonic.