David Sinclair· PhD
Critics said sirtuins have nothing to do with the benefits of calorie restriction or with longevity
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Critics said sirtuins have nothing to do with the benefits of calorie restriction or with longevity
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Shortly thereafter, Su-Ju Lin (and my fledgling lab at Harvard) found that caloric restriction activated SIR2, which helped explain why eating less extended lifespan—it wasn’t just about fewer calories, it was about flipping a longevity switch