The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
what experiments are most informative and in my view by far the most informative experiments are what is in the blood of young mice that is so good and what is in the blood of I don't know would you want to go on that fishing Expedition until you at least saw a signal in the people are doing it
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
A lot of the problems that parabiosis research faces at the moment is that that's really laborious and tricky to find out in any kind of systematic way. The few hits that people have had so far in terms of factors that seem to actually have some kind of causal role like GDF11...And so these things we found more or less serendipitously. And everyone knows that there's likely to be a number of others out there, perhaps very likely to be ones that are more central to the effect, but which have not been found just because they're a little more counterintuitive.
You know, things that may simply not be amenable to rejuvenation by measures like plasma exchange, but only by, from that parabiosis. Then we would have to look at a different model.