David Sinclair· PhD
Mammalian SIRT1 & SIRT6 proteins are the two closest in function to yeast SIR2. They control the epigenome, among other things…
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Mammalian SIRT1 & SIRT6 proteins are the two closest in function to yeast SIR2. They control the epigenome, among other things…
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
There are 7 SIR2-like genes or “sirtuins” in mammals: SIRT-ONE to SIRT-SEVEN. Even though the name seems similar, SIRT-TWO is a distant cousin of yeast SIR2…