Catalogs of gene expression changes in activated T cells can help understand T-cell activation and immunotherapy.

“so we could see • you know hundreds and thousands of genes changing as we • manipulated • the cells and so building a catalog of all the genes that • that are turned on or down regulated turned off when you activate t cells using different signals and that catalog then of course has been very helpful for subsequent studies in better understanding and teasing apart • the • mechanism of t-cell activation which has gotten increasingly more interesting of course now with the advent of immunotherapy”