Long-term B9 supplementation may increase cancer incidence and all-cause mortality, with the effect correlated to folate concentration in blood, and buckwheat extract's B vitamins may accelerate aging-associated epigenetic changes by driving genome methylation. — Whalespan
Long-term B9 supplementation may increase cancer incidence and all-cause mortality, with the effect correlated to folate concentration in blood, and buckwheat extract's B vitamins may accelerate aging-associated epigenetic changes by driving genome methylation.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
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High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“As for the vitamin-B rich Buckwheet extract, B vitamins drive the methylation cycle, which drives up wide genome methylation as seen in this large elderly cohort study (7), potentially accelerating the aging-associated epigenetic changes. Furthermore, long-term B9 supplementation increased cancer incidence and all cause mortality, with the effect specifically correlated to the folate concentration in the blood (8).”