David Sinclair· PhD
Accumulation of fat in old tissues was greatly reduced. All health-related blood biomarkers they assessed (lipids, liver function, blood cells) "were altered towards the values of young rats, without exception."
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Accumulation of fat in old tissues was greatly reduced. All health-related blood biomarkers they assessed (lipids, liver function, blood cells) "were altered towards the values of young rats, without exception."
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Level of oxidative stress, and (wait for it) senescent cells were reduced "by a very considerable degree".
Now to this new paper by Nugenics Inc. & Horvath: 18 rats were divided into three groups. 6 young rats (30 weeks old), 6 old rats (109 weeks old) & 6 old rats (also 109 weeks old) treated with plasma fractions from the young rats.