Extrapolating heart failure mechanisms from mouse studies to humans requires caution due to differences in disease progression.

“so i guess the next question would be what evidence have you seen that we that we could reasonably extrapolate this back to humans in terms of heart failure you mentioned that heart failure is something that's been increasing certainly cardiovascular disease in general has been skyrocketing and that gets into the mechanisms of atherosclerosis which will save potentially for a separate podcast but what do you think i mean how translatable are these mechanisms in mice with the mitochondria to humans well they seem to be directly translatable”