David Sinclair· PhD
First big discovery: DNA instability & epigenetic changes are a universal cause of aging (1996-1999).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
First big discovery: DNA instability & epigenetic changes are a universal cause of aging (1996-1999).
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell
Mitochondrial dysfunction, genome instability and epigenetic noise appear to be central drivers of yeast and possibly human aging.
Leverages work I did with Lenny Guarente and team in the 1990's showing that epigenetic information loss (triggered by DNA instability) is a cause of aging...