The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Dudley @LammingLab, a hero who, as a student, showed in @ScienceMagazine that multiple yeast sirtuins are required for calorie restriction to extend lifespan in yeast & are redundant, so deleting one gene doesn’t have a huge effect.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Dudley showed all yeast Sirtuins mediate CR (Science)
And we found that if we deleted that sirtuin gene in the yeast, either one of them or multiple ones, then caloric restriction in the yeast didn't work anymore, which showed us, told us that this wasn't just glucose being bad for you.
and that's also now being shown by others to be true in mice as well
there are aspects of of calorie restriction benefits such as a lifespan extension that are ameliorated lessened by us or to knockout but it's still complexified by the fact that it's lethal in embryos and you have to knock it out in the adult to do a really
if you knock outs or two you don't get the benefits of character benefits of CR right
And if you get rid of the sirtuin or SIR2 gene, the real breakthrough was that now calorie restriction doesn't work anymore.