IHHT protocols may contribute to brain rejuvenation and cognitive enhancement by increasing APP110, MMP9/2, and decreasing NETs, potentially slowing cognitive decline and maintaining reaction times in individuals with mild cognitive impairment.

“Brain rejuvenation and cognitive enhancement Study design and conditions Participants: 13 healthy individuals and 16 with mild cognitive impairment (MCI). Protocol: 3 weeks, 4 weekly sessions. Session Structure: Alternating 5-minute intervals: four at 12% O2 (hypoxia) and three at 33% O2. Key findings In both healthy and MCI participants: Brain rejuvenation: Increased APP110 was observed. Improved vascular and tissue repair and regeneration: Increased MMP9 and MMP2 levels were noted. Decreased systemic inflammation: Lower NETs were found. In MCI participants: Reduced amyloid beta expression. Slowed cognitive decline and maintained faster reaction times. Potential stress-response: The IHHT protocol increased circulating GDF-15, indicating a mitochondrial stress response. A transient increase in GDF-15 can signify protocol efficacy, whereas a chronic increase is associated with aging and frailty.”