David Sinclair· PhD
Psilocin notably increased levels of Sirtuin 1 (SIRT1), a protein known to regulate cellular aging, oxidative stress, and DNA repair, which might explain these results in part
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Psilocin notably increased levels of Sirtuin 1 (SIRT1), a protein known to regulate cellular aging, oxidative stress, and DNA repair, which might explain these results in part
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It also reduced markers of aging like β-gal activity, boosted sirtuin (SIRT1) levels, lowered DNA damage and oxidative stress, and preserved telomeres.
In vitro, psilocin (psilocybin’s metabolite) extended cellular lifespan by 29% at baseline and 57% at higher doses.