Andrew Huberman· PhD
And there tends to be, especially with certain strains of cannabis, increase in appetite, so-called munchies, and that has everything to do with very, very high density of CB1 receptors in the hypothalamus, and in particular areas of the hypothalamus, like the arcuate nucleus of the hypothalamus, other areas as well, of course, that have tons of CB1 receptors, bind THC and CBD and activate the neurons that strongly stimulate appetite through two mechanisms, one is a cognitive mechanism of creating a preoccupation with food in anticipation of taste, as well as the experience of taste. So the narrowing of focus to what you want to go eat. You really crave, I dunno, pizza. It seems to be high fat, high carbohydrate foods, but really crave pizza and narrowing of focus, so that you're not thinking about anything else, but also signaling from the hypothalamus to the gut to neurons within the stomach, itself, that regulate blood sugar, so there are strong effects on blood sugar of THC and CBD that generally lead to increases in appetite, so two parallel mechanisms, one within the brain, one within the body, increasing appetite.