Bryan Johnson· Author
Most interestingly is a gene called Plp1, which plays a big role in the insulation of neurons in the brain, which is essential for nerve signal transmission and neuronal function.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Most interestingly is a gene called Plp1, which plays a big role in the insulation of neurons in the brain, which is essential for nerve signal transmission and neuronal function.
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Increases in the expression of several X-linked genes were identified in the hippocampus of aging female mice.
The findings are also relevant in humans as higher expression of Plp1 was identified in the hippocampus of aging women than aging men, as demonstrated by postmortem gene expression analysis in human brains.
The delivery of this Plp1 gene to the hippocampus using viral vectors improved cognition both in aging male and female mice.