David Sinclair· PhD
Kevin & Jason showed Sirtuins can be activated by molecules (Nature & Science)…
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Kevin & Jason showed Sirtuins can be activated by molecules (Nature & Science)…
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Small molecules could activate SIRT1 (2003–2013).
we could activate longevity regulatory enzymes like SIRT1 with small molecules
A class of compounds both natural and chemically synthesized has emerged as sirtuin activators, binding typically in the N-terminal domain
Sirtuin modulation may have beneficial effects on aging and age-related diseases; thus, attracting a growing interest in discovering small molecules modifying their activity
With the advancement in research in this field, various small molecules, both natural and chemically synthesized compounds, have emerged as activators of sirtuins that can alleviate the conditions associated with aging and age-related diseases
Then in 2003, we published SIR2 and SIRT1 could be activated by small molecules, which is dogma today and shown for other sirtuin enzymes, but was highly controversial for a while
It's easier to find a safe, natural molecule that does the same thing.