Psychedelic experiences can alter the sense of self, including personality traits and a person's relationship to the world.

“That's the way one holds the sense of self, the fundamental relationship of a person in the world. I mentioned earlier, that these experience seems to alter the models we hold of reality, and I think the self is the biggest model, that I am a thing that's separate from other things. I am defined by certain... I have a certain personality, and I'm a smoker that's having a hard time quitting, or I'm a depressed person that views myself as a failure, and all of these things, those are models too.”