Peter Attia· MD
And it's not to say that taking a pill that lowers your cholesterol doesn't improve outcomes, but it's not going to come close to improving outcomes as much as this does on average.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
And it's not to say that taking a pill that lowers your cholesterol doesn't improve outcomes, but it's not going to come close to improving outcomes as much as this does on average.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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And if you think about that, that's much more frankly impressive from a physiologic perspective than taking a pill that lowers your cholesterol. And it's not to say that taking a pill that lowers your cholesterol doesn't improve outcomes, but it's not going to come close to improving outcomes as much as this does on average.
if you look at all the predictors of all cause mortality, which remember that's the holy grail metric of longevity, cardiorespiratory fitness outperforms every other variable we can measure. This includes blood pressure, this includes cholesterol, this includes BMI, smoking, it even includes age, which just blows my mind.