David Sinclair· PhD
In this 2023 paper, we showed age-related DNA methylation changes are accelerated by DNA breaks
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In this 2023 paper, we showed age-related DNA methylation changes are accelerated by DNA breaks
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In this paper, we show DNA breaks are a major driver of epigenetic change. We experience these in the trillions every day in our bodies. These advance the DNA methylation or "Horvath Clock"
A study @NatMetabolism shows mitochondrial DNA defects - one of the 8 hallmarks of aging - cause breaks in nuclear DNA, the kind we find accelerate the epigenetic clock & age-related diseases👇
A study @NatMetabolism shows mitochondrial DNA defects - one of the 8 hallmarks of aging - cause breaks in nuclear DNA, the kind we find accelerate the epigenetic clock & age-related diseases👇