David Sinclair· PhD
Ana-Maria Cuervo has shown in mice if you stop the age-related decline in the LAMP2A protein, which promotes "chaperone-mediated" autophagy (CMA), aspects of aging are slowed
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Ana-Maria Cuervo has shown in mice if you stop the age-related decline in the LAMP2A protein, which promotes "chaperone-mediated" autophagy (CMA), aspects of aging are slowed
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these retinoic acids control that pathway of autophagy through a protein called LAMP2A. What's exciting about Ana Maria's work is just this year, she published that if you upregulate that mechanism, this chaperone-mediated autophagy, mice live a lot longer. 30, 40% longer.