A weakness of the genetically heterogeneous mouse model is that shared mitochondria can significantly impact research outcomes due to genotype interactions. — Whalespan
A weakness of the genetically heterogeneous mouse model is that shared mitochondria can significantly impact research outcomes due to genotype interactions.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“and there's there's one kind of weakness that i'd i'd like to see them work on and maybe they will and that's this because of the breeding scheme that they use all of the mice have the same mitochondria no matter how genetically diverse they are they all have the same mitochondria and we now know that the mitochondrial genotype because it interacts so closely with the nuclear genotype can have a huge impact”