Most cancers are primarily caused by somatic mutations, not inherited germline mutations.

“there are some cancers that are driven by germline mutations in other words there are a subset of cancers where just knowing you inherited a certain gene dramatically increases your risk of that cancer so the bracket mutation would be an example of that Lynch syndrome which is an acquired genetic syndrome would be an example of that where all of a sudden you have one of these mutations and the probability that you're going to get cancer is very high in the case of Lynch syndrome it's virtually guaranteed you're going to get cancer in the case of bracha it's not quite as high but depending on which variant of it it can be still quite high probably approaches 80% with at least one variant”

“cancer is um mostly about sematic mutations and not germal mutations meaning most of the time when a person gets cancer it is not based on genes that they were born with uh it's based on genes that were at one point normal that have since acquired mutations in their mutated State they no longer function normally the person develops cancer”

“cancer is um mostly about sematic mutations and not germline mutations meaning most of the time when a person gets cancer it is not based on genes that they were born with”