Paul Saladino· MD
Caloric restriction not only increased lifespan across evolutionarily distant organisms, but also reduced age-related diseases burden and functional decline in these studies.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Caloric restriction not only increased lifespan across evolutionarily distant organisms, but also reduced age-related diseases burden and functional decline in these studies.
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so you know that led to obviously a large body of literature since then studying the effect of caloric restriction in not just rodents rats and mice but also all sorts of simpler organisms invertebrates like fruit flies and c elegans and yeast and the common theme seems to be that again starting from laboratory conditions if you restrict nutrients by a whole variety of different different methods um you can increase lifespan and apparently increase health span proportionally at least proportionally
in pretty much every organism where it's ever been studied you can find evidence that caloric restriction slows aging again there are there are cases where that didn't happen where lifespan wasn't extended where lifespan was shortened maybe we want to talk about this at some point the interaction between genetics and environment and caloric restriction but in general that is the the take-home message is caloric restriction can slow aging in laboratory animals pretty much everywhere where it's been studied
so you know that led to obviously a a large body of literature since then studying the effect of caloric restriction in not just rodents rats and mice but also all sorts of simpler organisms invertebrates like fruit flies and celegans and yeast and the common theme seems to be that again starting from laboratory conditions if you restrict nutrients by a whole variety of different different methods um you can increase lifespan and apparently increase health span proportionally at least proportionally um
so over a very wide evolutionary distance in pretty much every organism where it's ever been studied you can find evidence that caloric restriction slows aging um uh again there there are cases where that didn't happen where lifespan wasn't extended where lifespan was shortened maybe we want to talk about this at some point the interaction between genetics and environment and caloric restriction but in general that is the the the take home message is caloric restriction can slow Aging in laboratory animals pretty much everywhere where it's been studied
caloric restriction as an intervention uh as a girotective intervention is the oldest one in the book. I I'm not really aware of an intervention where uh a non-getic intervention that has from from a longer standing perspective produced a more consistent outcome in terms of laboratory animals where you restrict them of calories and they're going to live longer.