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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Can calorie restriction increase lifespan? | Peter Attia and Matt Kaeberlein — Whalespan

Content›Video›Can calorie restriction incr…

Can calorie restriction increase lifespan? | Peter Attia and Matt Kaeberlein

Peter Attia6m · 2024-07-27

Claims Made

12

Claims Supported

8

Support Rate

67%

Support rate

8 of 12 claims supported

8 supported4 partial / not

Claims from this content

9

✓Well SupportedMice exhibit functional declines in all tissues and organs with age, similar to humans, including kidneys, heart, and brain.✓Well SupportedCaloric restriction has been established to increase lifespan and reduce age-related disease burden and functional decline in multiple animal model systems.◐Partially SupportedCaloric restriction's lifespan extension effect in mice may be primarily due to cancer prevention.✓Well SupportedCaloric restriction in rats led to a 40-50% increase in lifespan in early experiments.Partially Supported

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Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Caloric restriction reproducibly improves lifespan in mammals.

◐Partially SupportedCaloric restriction increases lifespan and healthspan.

?Limited ResearchCaloric restriction's lifespan increase in mice may be due to cancer prevention rather than direct aging prevention.

◐Partially SupportedMice have a higher mortality rate from cancer compared to humans, with approximately 75-80% dying from cancer.

◐Partially SupportedLaboratory mice typically die from cancer, unlike humans who often die from atherosclerosis.