Paul Saladino· MD
gain-of-function mutations in fox oh three are associated with longevity and loss of function mutations in igf-1 are associated with longevity as well
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gain-of-function mutations in fox oh three are associated with longevity and loss of function mutations in igf-1 are associated with longevity as well
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we were looking at a relatively common mutation I'm saying common because it's like three four percent in the population where they have a complete deletion of exon 3 in the growth hormone receptor okay so one of the exomes the you know one of the things that are important for the integrity of this hormone right is deleted and of course you would think that that means that the growth hormone is less effective and Gillett smonny was fella with me brought me this data to suggest that while it's 3 4 percent in our control population it's 12 percent in our centenarians
well the FOXO genes of course being probably the most ubiquitous across that genes in the igf family the ghr families of growth hormone receptor family a possi 3 family those would be the biggest ones and blank me correct me if i'm blanking on anything but I think the big big ones are a possi 3 a bowi obviously FOXO 3 a IGF ghr I think are the top 5
60 it's the most common genotype it's not only genotypes by the way it's it's micro rna it's genotypes on the igf receptor it's deletions of the growth hormone receptor there's lots of ways to to get to this but this is very common
our centenarians have deletion of exon 3 in the growth hormone receptor and gil came to me and showed also the trend okay and as i said the trend is important so the homozygosity was three percent in our population and twelve percent in centenarians okay and i said gil what's their what's their igf-1 level and he showed me it's significantly lower i said terrific what was their maximal height and he said that's the problem and he shows me they're significantly taller than the rest of the people two three inches taller
polymorphisms that are associated in the igf-1 receptor Gene which decreases the igf-1 levels is associated with the longevity in centenarians
The FOXO3 genetic pathway, which I've talked about in multiple podcast and videos, is very closely related to human longevity. For example, humans that have a gene polymorphism in the FOX3 gene that make it more active are 2.7 times more likely to live to be a centinarian.
There's also human data showing that there's polymorphisms in, for example, the IGF-1 receptor, or that whole pathway, you know, that are also consistent with longevity as well.