Bryan Johnson· Author
System age clocks showed a 4.85 and 2.55 year of BA reduction with bi-weekly TPE with IVIG, and stand-alone monthly TPE, respectively.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
System age clocks showed a 4.85 and 2.55 year of BA reduction with bi-weekly TPE with IVIG, and stand-alone monthly TPE, respectively.
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additionally the bi-weekly TPE+IVIG protocol uniquely set back the inflammation and liver aging clocks compared to stand alone monthly TPE.
The bi-weekly TPE&IVIG (protocol 3) and the monthly TPE (protocol 1) protocols showed significant biological age reduction According to the average of all 36 aging clocks, the TPE&IVIG intervention yielded the highest average biological age (BA) reduction of 2.61 years, followed by the monthly TPE protocol yielding an average BA reduction of 1.32 years.