Andrew Huberman· PhD
because the half life of nicotine from smoking or vaping is very short, anywhere from one to two hours, they're essentially in a state of withdrawal at the point where they wake up in the morning.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
because the half life of nicotine from smoking or vaping is very short, anywhere from one to two hours, they're essentially in a state of withdrawal at the point where they wake up in the morning.
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Withdrawal sets in about four hours after the last ingestion of nicotine by cigarette or by inhalation from the vape pen.