David Sinclair· PhD
The beneficial effects of CR are mediated through the nutrient sensing proteins, and sirtuins being one of the proteins, its activators can play an enormous role in therapeutics
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The beneficial effects of CR are mediated through the nutrient sensing proteins, and sirtuins being one of the proteins, its activators can play an enormous role in therapeutics
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well then we discovered that the sirtuins are regulated and need nad and suddenly all of the work that we've been doing on caloric restriction and aging made sense
we then we discovered that the cirtuins are regulated and need nad and suddenly all of the work that we've been doing on caloric restriction and aging made sense and i need to credit lenny guarente and shin am i my great colleagues who i work with at mit who made that seminal discovery now we could link metabolism and nad to longevity genes and longevity and that was a real breakthrough
but then we discovered that the certuans are ra regulated and need nad and suddenly all of the work that we've been doing on caloric restriction and aging made sense and i need to credit lenny guarente and shin am i my great colleagues who i work with at mit who made that seminal discovery Now we could link metabolism and nad to longevity genes and longevity and that was a real breakthrough