The taste system is malleable and subject to learning and experience, with desensitization occurring at multiple neural stations.

“Can you imagine a sort of a system by which people could leverage that where does this this desensitizing happens that's the term that we use I think it happening at multiple stations it's happening at the receptor level i.e. the cells in your tongue that are sensing that sugar as you activate this receptor and it's triggering activity after activity after activity eventually you exhaust the receptor again I'm using terms which are extraordinarily loose the receptor gets to a point where it under goes a set of changes chemical changes where it now signals far less efficiently or it even gets removed from the surface of the cell and that is a huge side of this modulation.”