A framework involving multiple clocks, established controls, and assessment of sensitivity/consistency is emerging to reliably benchmark epigenetic aging clocks.

“To reliably benchmark and compare epigenetic aging clocks for assessing rejuvenation and longevity interventions, they have established the following framework: + Evaluating interventions and datasets using multiple clocks. + Employing well-established interventions known to either accelerate or decelerate aging as reliable controls for clock testing. + Assessing the sensitivity and consistency (harmony) of clocks in measuring the effects on biological aging.”