David Sinclair· PhD
Sir2, the OG Sirtuin, is a chromatin silencing protein that controls the epigenome and suppresses recombination at rDNA. More silencing, less DNA recombination, fewer ERCs, longer lifespan
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Sir2, the OG Sirtuin, is a chromatin silencing protein that controls the epigenome and suppresses recombination at rDNA. More silencing, less DNA recombination, fewer ERCs, longer lifespan
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Overexpression (OE) of SIR2 extended yeast lifespan by suppressing rDNA instability
you can do is the opposite you can turn on or over express the surtout gene in a yeast cell and if we're right you should get a few things that are gonna happen you'll have more genomic stability at this particularly this our DNA locus in the nucleolus and the yeast cells should live longer