Short-term negative physiological responses from an intervention do not necessarily predict negative long-term health outcomes.

“So let's just take exercise, for example. If you didn't know anything about exercise, and I said to you, Andrew, I'm going to do something that's going to make you-- your heart rate go up, your blood pressure go up, your inflammatory markers go up, your reactive oxygen species increase, you're going to say-- and it's going to damage your muscles, you're going to say, I'm not doing that. That sounds horrible. But it does all those things in the short term. But what is the long term effect of exercise? You actually get healthier.”