Inflammaging signals from senescent cells induce energy conservation behaviors like apathy and muscle shrinkage.

“Uh, and then they send signals and those signals are the same signal that we release during sickness behavior. If your immune system is like really struggling energetically because it's trying to fight off a virus, it's going to send those same cytoines. And when those cytoines reach the brain, the brain says, "Oh [laughter] >> we're going to go bankrupt." you know the energy budget is is threatened here. So let's save energy and then you become apathic, you become cold, you shrink your muscles and those are all good energy saving energy conservation strategies to a viral infection, right? The same thing seems to happen slowly as you age if you have those cells that are sending those signals.”